Jacquelyn Dosal, MD
University of Miami, Department of Dermatology
2011 Research Grant Recipient
Research Grant Proposal
Effect of Tetracyclines on the Development of Vascular Disease in Veterans with Acne or Rosacea
Study sponsor: Jonette Keri, MD, PhD, FAAD
Abstract: Acne and rosacea are two chronic diseases that can be socially debilitating for patients. Systemic treatment with tetracyclines is quite effective for both conditions. In addition to their antibacterial properties, tetracyclines are increasingly being used for other non-antibacterial properties, for instance their anti-inflammatory properties. These qualities may have secondary benefits and a protective effect on other organ systems, such as the cardiovascular system. In this study, we will test the hypothesis that anti-inflammatory medications such as doxycycline or minocycline in acne and rosacea patients have secondary benefits on the cardiovascular system. Our specific aim is to determine whether use of doxycycline or minocycline in acne and rosacea patients correlates with a decreased development of vascular diseases. We will perform a retrospective cohort study to analyze the electronic records at all medical centers of the Veterans Integrated Service Network-8, and determine whether there is a correlation between long-term (>3 months) use of doxycycline or minocycline for acne or rosacea and the incidence of vascular diseases (cardiovascular disease, cerebrovascular disease, atherosclerosis, and development of aortic aneurysms). Veterans will be searched according to ICD-9 codes for acne, rosacea, and cardiovascular disease. Patients will be subdivided according to those who received a tetracycline and those that did not. Confounding conditions such as diabetes mellitus, dyslipidemia, and hypertension will be accounted for in the analysis. Acne and rosacea patients will be analyzed separately.
Publication
JR Dosal et al. Effect of Tetracyclines on the Development of Vascular Disease in Veterans with Acne or Rosacea: A Retrospective Cohort Study. Journal of Investigative Dermatology (2014) 134, 2267–2269; doi:10.1038/jid.2014.148; Published online 24 April 2014
View Dr. Dosal’s published manuscript