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AARS Hot Topics - May 2, 2017 Issue


The AARS online Hot Topics Newsletter is an exclusive AARS member benefit!

This is a semi-monthly compilation of peer-review literature and online updates in acne and rosacea covering industry press, new medical research and what patients and your peers are talking about in patient counseling tips.

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Industry News

  • The AARS held their 6th Annual Scientific Symposium at the Society of Investigative Dermatology Meeting in Portland, Oregon. The Symposium was a great success. Please check back on the AARS website to view the talks this month!
  • Sienna Biopharmaceuticals announced it has completed a $40 million, Series B financing to advance its diversified topical biotech pipeline. The clinical stage medical dermatology and aesthetics company is developing lead assets including SNA-120 for pruritus and psoriasis, and SNA-125 for atopic dermatitis, psoriasis and pruritus, and through a photoparticle therapy platform, SNA-001 for treating acne vulgaris and permanent reduction of unwanted light-pigmented hair, according to a news release.
  • According to new research published online April 20, 2017 in the Journal of the American Academy of Dermatology, increased consumption of alcohol, particularly white wine and liquor, is associated with a higher risk of rosacea in women.
  • Dermata Therapeutics and Villani announced they have entered into an exclusive global license agreement for Dermatta to develop Villani's natural sponge product as a potential treatment for a variety of skin diseases, including acne.

New Medical Research

  • A blocked-randomized, split-faced 595-nm PDL (fluence 8 J/cm3 pulse duration 10 ms, spot size 7 mm, 2 session every 2 weeks) study was conducted in patients with mild to moderate acne to look at the efficacy and patients' satisfaction of 595-nm pulse dye laser (PDL) treatment of acne vulgaris and acne erythema in adolescents and early adulthood.
  • Results from a prospective, single visit photographic study to assess inter-rater agreement of acne photographs shared through an integrated mobile device, cloud-based, and HIPAA-compliant platform support the use of mobile phone based photography and cloud-based image sharing for acne assessment.
  • A study to evaluate the efficacy of fractionated microneedle radiofrequency (FMR) vs FMR combined with subcision for the treatment of atrophic acne scars showed the combination of subcision and FMR is a safe and effective modality for mixed type acne scars.
  • A cohort study to determine the association between alcohol intake and the risk of rosacea in women found that, compared with never drinkers, increased alcohol intake was associated with a significantly increased risk of rosacea in women.
  • Findings from a new study support that Cutibacterium (Propionibacterium) acnes (C. acnes) strains from clonal complex CC18 and the often antibiotic resistant clone ST3 are associated with acne and suggest that susceptibility of the host rather than differences within these clones may determine the clinical outcome of colonization.
  • A case control study of animal model of Modic changes (MCs) on rabbits to evaluate the feasibility of inducing of MCs by injection of Propionibacterium acne (P. acnes) into the lumbar intervertebral discs of rabbits found that P. acnes incubation in the disc can induce degeneration of the disc and an inflammatory response in the endplate region, presenting as MCs type I and II time-dependently.
  • A new study presents preliminary findings of Thai female facial skin microbiome using three pooled samples from groups of skin microbiome profiles, namely (1) healthy and (2) acne-prone young adults (teenage.hea and teenage.acn) and (3) healthy elderly adults (elderly.hea) based on standard dermatological criteria. Significant differences were found among orders of bacteria, pointing to possible differences in human ecto-flora.
  • Investigators looking at the efficacy of topically applied synthetic epidermal growth factor (EGF) serum in reducing the appearance of atrophic acne scars in skin of color found that topical EGF may improve the appearance of atrophic acne scars in skin of color.
  • Findings from a recent study designed to mimic isotretinoin treatment in young patients by using the dosage of 1mg/kg, and a higher one of 10mg/kg, for 60days in young male Wistar rats suggest that while some patients on isotretinoin have described intestinal symptoms, no important alterations were found with this protocol.
  • Having previously shown that mast cells (MCs) are the key mediators of LL37-induced rosacea inflammation (Muto et al., 2014), investigators sought to determine what factors lead to the increased activation of MCs and the increased release of their mediators in rosacea skin.
  • Signaling mechanisms causing increased expression of TRPV4 in rosacea paitents await elucidation. Investigators of a recent study look at whether TRPV4-mediated Ca++-influx evokes mast cell degranulation.
  • A recent study to determine the significance of quantitative analysis of parallel-polarized light (PPL) photography images in rosacea patients found that this technique using PPL images is applicable to the quantitative and objective assessment of rosacea in clinical settings.
  • Results from a placebo-controlled, randomized, double-blind, parallel-group, comparative, multicenter study to investigate the efficacy and safety of benzoyl peroxide (BPO) gel, administrated once daily for 12 weeks to Japanese patients with acne vulgaris suggest that both 2.5% and 5% BPO are useful for the treatment of acne vulgaris.
  • A new report highlights a case on a necrotizing facial wound due to Acne fulminans (AF), also known as acne maligna, that was successfully treated with oral prednisolone and antimicrobial medication.
  • Findings from a new study show a ready-to-use peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved the cosmetic appearance of adult female acne (AFA) by reducing cutaneous androgen content and promoting skin autophagy.
  • According to a recent study, using a combination of subcision and laser had suitable for improving atrophic acne scars.

Clinical Reviews

  • A survey to collect information about how people with acne make day-to-day decisions concerning the effectiveness of their treatment showed that although the most frequently used methods were namely physician-assessed changes in lesion counts and global acne severity, people with acne often take into account several factors that cannot be assessed by a third party at a single point in time.
  • A new article aims to review the structure, mechanisms of action, and adverse effects of retinoids, as well as some of their current uses in dermatology.
  • A recent paper comprehensively reviews the medical literature regarding skin needling efficacy and safety in all skin types and in multiple dermatologic conditions.
  • A Cochrane review of randomized controlled trials (RCTs) evaluating the effects of light-based interventions for acne vulgaris found that most studies reported adverse effects, but inadequately, with scarring reported as absent, and blistering only in studies on intense pulsed light, infrared light and PDT (very low QE).
  • A retrospective, comparative study carried out in Poland and Romania from January 2012 to August 2016 to estimate the adverse effects after isotretinoin by treatment of 3,525 patients due to acne vulgaris documents the adverse effect profile of isotretinoin in a large number of patients collected over a period of 4 years. Side effects were mild and well tolerated and did not necessitate stopping the treatment.

Patient Counseling / Communication

  • A recent article reports on 6 healthy male adolescent patients who developed acne located only to the trunk after the consumption of whey protein supplements for faster bodybuilding. This is the first observation which specified the location of acneiform lesions among bodybuilders.