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AARS Hot Topics - April 3 2017 Newsletter


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This is a semi-monthly compilation of peer-review literature and online updates in acne and rosacea covering industry press, new medical research and what patients and your peers are talking about in patient counseling tips.

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Industry News

  • Galderma’s Differin Gel 0.1% (adapalene) is now available over the counter (OTC) at major retail and drug stores. Galderma officially launched the gel at a New York City media fete, and the skin care company came out of the gate in a very big way --a new commercial, a splashy digital campaign, a celebrity spokesperson and of course, a hashtag -- #differin.
  • Sun Pharma introduced a new initiative— “Leave Acne Behind™" — to educate patients and create awareness of severe recalcitrant nodular acne (SRNA).
  • The FDA has approved Allergan's RHOFADE™ cream for the topical treatment of persistent facial erythema associated with rosacea in adults. Approval was based on two clinical studies that evaluated the primary efficacy endpoint on day 29.

New Medical Research

  • In two phase III trials of 12 weeks' duration in patients aged ≥12 years with moderate acne vulgaris, once-daily dapsone 7.5% gel was shown to be an effective and well tolerated option for the topical treatment of acne vulgaris in this patient population.
  • A nationwide cohort study to investigate the association between rosacea and coeliac disease (CeD), Crohn disease (CD), ulcerative colitis (UC), Helicobacter pylori infection (HPI), small intestinal bacterial overgrowth (SIBO) and irritable bowel syndrome (IBS), found that rosacea is associated with certain gastrointestinal diseases, but the possible pathogenic link is unknown.
  • A very small study to evaluate acute HS lesions for the presence of bacterial biofilms found that only 2 of 10 patients showed presence of bacterial biofilm. The absence of biofilm was an unexpected finding given the fact that the environment of intertriginous areas is highly favourable for bacterial proliferation and biofilm formation in the skin.
  • Investigators of a recent study found that there were no differences in the decreased levels of inflammatory factors between hidradenitis suppurativa patients with and without NCSTN mutations. This result may indicate that NCSTN mutations have no direct effect on inflammatory cells in the process of cytokine production.

Clinical Reviews

  • The global ROSacea COnsensus (ROSCO) expert panel has issued a new recommendation to establish a phenotype-led rosacea diagnosis and classification, as well as a recommendation on phenotype-based treatments for signs and symptoms presenting in individuals with rosacea.
  • The findings of a new study prompt clinicians working in primary care in the U.K. to review their prescribing habits and make changes to ensure that they are in line with current guidance.
  • A new study looks at the rate of primary-care consultations and follow-up consultations; prescribing patterns, including overall use of acne-related medications (ARMs); and initial and follow-up prescription for acne vulgaris in the U.K.
  • An investigation of possible differences in the number of patients treated for hidradenitis suppurativa (HS) in various Norwegian health regions in order to explore the variation in prevalence rates suggested that such prevalence estimates are likely to be biased by awareness and intention to treat.
  • A recent article highlights the need for the classification guidelines for rosacea to be re-evaluated in order to incorporate current scientific knowledge and address shortcomings in the diagnosis and classification of rosacea.
  • In response to the Egeberg et al. articlepublished in the British Journal of Dermatology 2017, researchers suggest that epidemiological studies such as Egeberg’s cannot, by definition, prove causality of an observed association, because distortion by biases and confounders can never be ruled out entirely. Such studies are, nevertheless, of great value to medicine and to public health, as they open our eyes to novel pathophysiological hypotheses and biological pathways, which in turn may stimulate new research ideas, potentially leading to the development of new treatment options.

Patient Counseling / Communication

  • An article in the April issue of Allure magazine highlights what’s happening in acne today. Adult female acne, acupuncture, the association between acne and dairy, and the various medications used to treat acne are topics explored in this article.
  • A pilot program to explore how patients may interact with cell phone technology to supplement medical care beyond patient reminders demonstrated a very high satisfaction with the program by helping patients follow their acne treatment recommendations.
  • Growing incentives to control health care costs may cause accountable care organizations (ACOs) to reconsider how skin disease is best managed. A new study assessed the cost of seeing a dermatologist versus a PCP for diagnosis of psoriasis and rosacea.
  • The connection between mind and skin is so entangled that it has spurred the creation of a micro-specialty called psychodermatology. In psychodermatology, mental health professionals and dermatologists work together to treat acne.
  • A recent review article shows finds that given the increasing importance of patient-reported outcomes in the evaluation of healthcare quality, future comparisons of patients’ judgements about care may need to account for differences in their expectations for care.