March 1 2017 Issue

The AARS online Hot Topics Newsletter is an exclusive AARS member benefit!

This is a semi-monthly compilation of peer-review literature and online updates in acne and rosacea covering industry press, new medical research and what patients and your peers are talking about in patient counseling tips.

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Industry News

  • Institute scientists have revealed a potent inflammatory molecule released by dying cells triggers inflammation during necroptosis, a recently described form of cell death linked to inflammatory disease. The discovery could lead to new and existing medicines that target the molecule being investigated as a way of treating inflammatory diseases.
  • Hologic and Cynosure announced today that they have signed a definitive agreement in which Hologic will acquire the medical aesthetics company, according to a press release.

New Medical Research

  • A new case study shows how İsotretinoin may affect the functioning of the RPE and can cause the development of subretinal fluid and serous retinal detachment.
  • Another recent case study describes clinical and genetic characteristics of two unrelated patients with hidradenitis suppurativa (HS) and familial Mediterranean fever (FMF). The analysis suggests that HS is associated with yet another inflammatory disorder.
  • According to results of a recent study, healthy sebaceous gland rich (SGR) skin is characterized by a distinct, non-inflammatory immune surveillance, which may explain the preferred localization of inflammatory skin diseases, and can influence future barrier repair therapeutic concepts.
  • An exploratory study investigated the characteristics of the skin microbiota in subjects with acne and determined microbiota changes after 28 days of application of erythromycin 4% or a dermocosmetic. The dermocosmetic decreased the number of Actinobacteria and Staphylococcus spp. after 28 days.
  • Results of a new study show that the S10 protein amino acid substitution contributes to reduced doxycycline susceptibility in P. acnes and suggests that tetracycline resistance is acquired through a 16S rRNA mutation after the S10 protein amino acid substitution causes reduced susceptibility.
  • Permethrin 5% gel can significantly reduce the Demodex density (Dd) and severity of presentations in rosacea patients and can be a safe and effective option in the management of this chronic disorder, according to a recently published article.
  • A recent case study describes how stress management and diet modification are key adjunctive therapies in the treatment of rosacea fulminans and need to be addressed more often in treatment. In cases where patients are reluctant or unable to take isotretinoin, an integrative approach may be effective in achieving symptomatic improvement.
  • Investigators of a new study propose an improved, automated, and more objective acne grading method which involves optimizing the k-means clustering algorithm by identifying the actual number of clusters rather than basing analysis on a fixed K= 3 assumption for all images.
  • A recent study describes a case of IFAG in a 13-year-old boy who showed a dramatic response to oral doxycycline and topical metronidazole, which supports the hypothesis that IFAG may belong to the spectrum of rosacea.

Clinical Reviews

  • A new article summarizes the relevant literature on the role of nicotinamide in acne vulgaris and discusses the next steps necessary to move this approach into clinical practice.
  • A study to determine current clinical practices relating to use of isotretinoin among dermatologists in the UK (including geographical variations) as measured against BAD standards found there is currently good compliance with standards. Certain aspects of care that are less frequently preformed, such as pregnancy testing post-treatment, are highlighted in this article.
  • A new review describes the most common skin-derived antimicrobial peptides/proteins (AMPs)/Host defense peptides/proteins (HDPs) (defensins, cathelicidins, S100 proteins, ribonucleases and dermcidin) and discuss the biology and both the positive and negative aspects of these AMPs/HDPs in skin inflammatory/infectious diseases. Understanding the regulation, functions and mechanisms of AMPs/HDPs may offer new therapeutic opportunities in the treatment of various skin disorders.
  • The current knowledge on the phages active against P. acnes described so far and their potential application in the treatment of acne associated with P. acnes is summarized in a recent article.
  • Topical anti-androgens, insulin-like growth factor-1 inhibitors, peroxisome proliferator-activated receptor-modulators, acetylcholine inhibitors, topical retinoic acid metabolism-blocking agents, vitamin D analogues, antimicrobial peptides, interleukin-1α and interleukin-1β blockers and immunotherapy are some novel treatment options for acne, as reviewed in a recent article.
  • The present review summarizes published data on PDT application in skin appendage disorders. Our literature review shows that PDT may be a suitable treatment for acne, folliculitis decalvans, hidradenitis suppurativa, nail diseases, and sebaceous hyperplasia.
  • Despite an increasing awareness of acne in the adult female population, there is a lack of good prospective studies assessing the severity, distribution, and differential response to treatment in this group. A new article offers a critical review of data from available literature on adult female acne.
  • A recent article present the possible molecular mechanisms of rosacea based on recent laboratory and clinical studies. Authors describe the genetic predisposition for rosacea along with its associated diseases, triggering factors, and suggested management options in detail based on the underlying molecular biology.

Patient Counseling / Communication

  • An investigation to explore understandings about the use of oral antibiotics for acne and advice shared amongst messages posted on online forums showed that online forums offer opinions that could be confusing or lead to early abandonment of treatments, challenging consultations and patient dissatisfaction. Users expressed frustration about the delayed onset of action of antibiotics for acne, perceptions of only temporary effectiveness and adverse effects.
  • A recent study assessed the cost of seeing a dermatologist versus a primary care physician (PCP) for diagnosis of psoriasis and rosacea. With diagnosis costs essentially equal and increased dermatologist diagnostic accuracy, accountable care organizations (ACOs) may encourage skin disease to be managed by dermatologists.