June 15, 2017 Issue

The AARS online Hot Topics Newsletter is an exclusive AARS member benefit!

This is a semi-monthly compilation of peer-review literature and online updates in acne and rosacea covering industry press, new medical research and what patients and your peers are talking about in patient counseling tips.

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Industry News

  • The AARS just completed the fourth roundtable meeting of the Scientific Panel on Antibiotic Use in Dermatology (SPAUD)! Stay tuned and check our website for future updates! See https://acneandrosacea.org/initiatives/spaud for more information in the coming weeks.
  • Foamix Pharmaceuticals Ltd announced that the first patient has been dosed in a phase 3 program to measure the efficacy and safety of FMX103, topical minocycline foam 1.5% for patients with with moderate-to-severe papulopustular rosacea.
  • BioPharmX Corporation announced comprehensive phase 2b clinical data results that showed BPX-01 2% reduced the number of inflammatory lesions in acne patients by 59% compared with 44% in vehicle, while also suggesting it may lessen the severity of lesions.
  • An unbalanced population of bacteria on the skin may play a major role in acne, according to a new, small study. One specific type of bacteria has long been suspected, but this study suggests the presence or absence of one particular strain is less important than the overall balance of bacteria on the skin.
  • A group of researchers at the University of California, San Diego are working on a vaccine to cure the skin condition. The vaccine is meant to rid the skin of bacteria that causes pimples and breakouts, without harming the microbes your body actually needs.

New Medical Research

  • Results from a cross-sectional study suggest a relationship between dietary carbohydrate, including glycemic load (GL), and acne.
  • According to a recent study, hyaluronate gel (HA) gel dispersed adapalene poly-Ԑ-caprolactone nanospheres (AD-NS) presented a non-irritant compromised cosmeceutical formulation suitable for oily acneic skin.
  • Results of a new study suggested a potential possibility of chitosan-phytochemical conjugates in the control of infections related to acne vulgaris.
  • A small study to investigate the efficacy of 50% glycolic acid peeling performed at different phases of menstruation on acne showed that that chemical peeling administered during ovulation provides the most significant benefit for acne lesions.
  • A study to compare the efficacy and safety of doxycycline 40 mg vs. minocycline 100 mg in papulopustular rosacea found that minocycline 100 mg is noninferior to doxycycline 40 mg in efficacy over a 16- week treatment period.
  • Two patient-reported outcome (PRO) questionnaires, the Hidradenitis Suppurativa Symptom Assessment (HSSA) and Hidradenitis Suppurativa Impact Assessment (HSIA), were developed to measure signs, symptoms, and impacts of HS in treatment efficacy studies.
  • A recent study demonstrated that the microbiome in hidradenitis suppurativa (HS) differs significantly from that in healthy controls in lesional and nonlesional skin, suggesting a link between a dysbiotic cutaneous microbiome and HS.
  • Treatment with topical tretinoin resulted in complete resolution of rosacea symptoms in a significant number of patients, in a small retrospective study presented at the annual meeting of the Australasian College of Dermatologists.

Clinical Reviews

  • A recently published investigation describes five cases of acneiform eruption caused by vitamin B12 in five females aged 37, 32, 62, 29, and 21 years, respectively.
  • In a new article, investigators review the reasons supporting retinoids as the mainstay of acne therapy and discuss some of the perceived barriers that may be limiting use of this important drug class.
  • Hormonal therapies are effective and well tolerated options for the treatment of acne vulgaris in adolescents with and without endocrine disorders, according to a recent review.
  • The present review describes the role of IL-1 in diseases with skin involvement and gives an overview of the relevant studies discussing the therapeutic potential of modulating the secretion and activity of IL-1 and IL-18 in such diseases.
  • A task force commissioned by the American Society for Dermatologic Surgery concluded that there is insufficient evidence to justify delaying treatment with superficial chemical peels and nonablative lasers, including hair removal lasers and lights, vascular lasers, and nonablative fractional devices for patients currently or recently exposed to isotretinoin.
  • According to expert analysis from the annual meeting of the American Academy of Dermatology, botulinum toxin may have a place in treating psoriasis and rosacea. A smattering of case reports have shown positive results and some clinicians are exploring their off label use, said Erin Gilbert, MD.
  • In a new article, investigators highlighted the main features of hidradenitis suppurativa (HS) (clinical aspects, epidemiology, pathogenesis, diagnostic criteria, classifications, comorbidities, and treatments), so that awareness of this disease might be heightened in primary care physicians and surgeons, who may be the first health care providers to see patients with this disease owing to its characteristic clinical presentation (inflammatory nodules, abscesses, sinus tract, etc.).
  • A retrospective study of 110 adult female patients with acne showed a dramatic improvement in their acne while treated with spironolactone. There were low rates of relapse or discontinuation of the medication.

Patient Counseling / Communication

  • A recently published segment on Fox News discusses the impact of teenage acne on self-confidence and suggests treatment and lifestyle changes to reduce the effects of the disease.
  • Patients with acne or rosacea consistently paid more for topical retinoids, topical antibiotics, and oral tetracyclines when the prescriber was a dermatologist instead of a family or internal medicine physician, Myron Zhang reported at the annual meeting of the Society for Investigative Dermatology.
  • Video blogger Katie Snooks, who posted videos about her acne treatment online, investigates how other people cope with the skin disease, as shared on BBC News.
  • In a video from the 75th Annual Meeting of the American Academy of Dermatology, Dr. Seemal R. Desai spoke about cosmetic treatment options for various disease states in patients with skin of color.