June 1, 2017 Issue

The AARS online Hot Topics Newsletter is an exclusive AARS member benefit!

This is a semi-monthly compilation of peer-review literature and online updates in acne and rosacea covering industry press, new medical research and what patients and your peers are talking about in patient counseling tips.

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Industry News

  • Actress and singer Kristin Chenoweth helped kick off a campaign for Rhofade Cream 1% for treating persistent facial erythema associated with rosacea, according to a news release from Allergan. Chenoweth, who has rosacea, will help raise awareness of rosacea and Rhofade Cream 1% (oxymetazolone chloride), which is available by prescription and indicated for topical treatment of persistent facial erythema associated with rosacea in adults, according to the release.
  • Madenco Biosciences has created a new line of cosmeceuticals. The SP-DERM line, based on Madenco’s proprietary SP-Technology platform, topically delivers molecules known as protein transduction-domain or cell penetrating peptides/proteins. The new products target recovery after intensive laser treatments, prolonging the effects of cosmetic procedures and minimizing the appearance of acne scars, according to a news release.

New Medical Research

  • A new study aims to compare real world treatment failure of extended-release minocycline (ERM) (once-daily branded formulation) and a twice-daily generic formulation (GM) among the ERM and GM formulations, and to compare administrative burden (patient phone calls, pharmacy messages) between these 2 formulations.
  • Results of a cohort study found alcohol intake was significantly associated with an increased risk of rosacea in women.
  • Findings from a recent study demonstrated that a combination regimen involving non-ablative fractional laser (NAF) and fractional micro-needling radiofrequency (FMR) could be a viable option for the treatment of acne scars with satisfactory efficacy.
  • Results of a cohort study to determine the association between smoking and risk of incident rosacea showed the risk of rosacea was significantly increased within 3-9 years since smoking cessation, and the significant association persisted among past smokers who had quit for over 30 years.
  • An investigation to determine an accurate and objective method for assessing the severity of rosacea found that color imaging systems can be useful and reliable for evaluating the severity of rosacea, in addition to biophysical parameter assessment.
  • A study to investigate antibacterial activity of ethanolic extract of cinnamon bark, honey, and their combination against acne bacteria showed that the combination of cinnamon bark extract and honey has potential activity against acne-causing bacteria.
  • Researchers examining the effect of systemic isotretinoin on olfactory function concluded from a recent investigation that isotretinoin therapy improves the sense of smell.
  • A study is to develop a topical preparation incorporating essential oils (EOs) for use against acne-associated bacteria found that a combination of 0.53 mg/mL litsea, 0.11 mg/mL rosewood and 0.11 mg/mL clove bud formulated into herbal distillates may serve as a valuable alternative for the control of acne vulgaris-associated bacteria.
  • Results of a recent study show using laser therapy in comprehensive treatment of patients with acne promotes the normalization or a tendency to normalization of the systemic immunity and phagocytosis with significant difference between the indices of the individuals who received a standard therapy alone.
  • A case-control study found small intestinal bacterial overgrowth (SIBO) was the most relevant factor in papulopustular rosacea. Its treatment was crucial in improvement and in maintaining the clinical remission.

Clinical Reviews

  • Findings from a recent meta-analysis show weak associations between rosacea and Helicobacter pylori infection as well as an effect of Helicobacter pylori therapy on rosacea symptoms, albeit that these did not reach statistical significance.
  • The National Rosacea Society Expert Committee (NRSCOR) 2002 publication indicated that the definition and classification system then proposed was based on scientific knowledge, that it was provisional, and that it would be refined with increasing knowledge. A move from subtyping towards a phenotype approach was proposed by the American Acne and Rosacea Society (AARS) and ROSCO presents the first international effort to advance the diagnosis and classification of rosacea.
  • A comprehensive review of evidence for isotretinoin therapy in acne patients suggests that isotretinoin is effective in reducing acne lesion counts, but adverse events are common.
  • A recently published review explores the multiple causes of acne and how plant-based foods and supplements can control these.
  • A retrospective chart review of the laboratory results of 246 patients who were treated with isotretinoin for acne over a 9-year period suggest that ALT and AST are not useful for monitoring isotretinoin therapy and that GGT and CK may be of greater value in managing patients.
  • A study to assess the cost-effectiveness from the payer perspective of using dermatologists versus pediatricians to treat acne in adolescents ages 10-18 Dermatologist treatment appears cost-effective related to producing additional quality-adjusted life years (QALYs) at a cost of less than $100,000 per QALY gained.
  • A retrospective analysis to determine the prevalence of hidradenitis suppurativa (HS) included a demographically heterogeneous population-based sample of more than 48 million unique patients across all US census regions. Results showed that HS is an uncommon, but not rare, disease in the United States that disproportionately affects female patients, young adults, and African American and biracial patients.
  • Investigators sough tto retrospectively compare field-directed ALA-PDT with blue light only, blue light + pulsed dye laser (PDL), blue light + intense pulsed light (IPL), blue light + PDL + IPL, or blue light + red light + PDL + IPL for inflammatory acne of the face or upper trunk. Results showed a trend toward greater patient-reported improvement with comparable tolerability using multiple, sequential light sources in ALA-PDT for acne vulgaris, albeit not statistically significant.
  • A structured review to determine the efficacy and safety of superficial chemical peeling in the treatment of active acne vulgaris found that chemical peeling with glycolic acid is a well-tolerated and safe treatment modality in active acne vulgaris while salicylic acid peels is a more convenient for treatment of darker skin patients and it showed significant and earlier improvement than glycolic acid.

Patient Counseling / Communication

  • A recently published paper briefly summarizes current knowledge in key areas including epidemiology, clinical presentation and morphological classification, natural history and prognosis, genotype-phenotype correlations, clinico-pathological correlation, pathogenesis, optimal treatment and outcome measures.
  • Debunking the my that moisturizers make acne worse in patients with oily skin suggest that acne patients can use noncomedogenic moisturizers to prevent and alleviate skin irritation and soothe the skin by slowing the evaporation of water.
  • A study to understand rosacea patients' online health information seeking habits in order to obtain a better insight of their educational needs showed that proactively providing reliable resources and comprehensive explanations on treatments, triggers, diet and skin care could be helpful in reducing patients' confusion about rosacea and enhancing rosacea patient-physician relationships.