April 18, 2017 Issue

The AARS online Hot Topics Newsletter is an exclusive AARS member benefit!

This is a semi-monthly compilation of peer-review literature and online updates in acne and rosacea covering industry press, new medical research and what patients and your peers are talking about in patient counseling tips.

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Industry News

  • At the Microbiology Society's Annual Conference, researchers showed that the overall balance of the bacteria on a person's skin, rather than the presence or absence of a particular bacterial strain, appears to be an important factor for acne development and skin health.
  • April has been designated Rosacea Awareness Month by organizations including the National Rosacea Society and the Acne and Rosacea Society of Canada. Developments reported on Healio.com/Dermatology include research presented at this year’s American Academy of Dermatology Annual meeting that microneedling with tranexamic acid solution was an effective treatment for rosacea and study results finding that rosacea may be tied to increased risk for inflammatory bowel disease.
  • April has been designated Rosacea Awareness Month in the United States and Canada to educate the public about the widespread facial disorder. The goal of Rosacea Awareness Month is to spread awareness about the disease that is estimated to affect more than 16 million Americans, so that more people who may have rosacea seek medical help before it gets worse, and to find greater public acceptance for those people whose lives are affected by the disease.
  • Allergan and Paratek Pharmaceuticals announced today that two phase 3 trials of sarecycline yielded encouraging 12-week results for the treatment of moderate-to-severe acne, according to a press release. The once-daily, oral, narrow-spectrum tetracycline-deprived antibiotic has anti-inflammatory properties.

New Medical Research

  • Japanese researchers investigated bactericidal activity and post-antibiotic effect (PAE) of ozenoxacin against Propionibacterium acnes, a major causative bacterium of acne vulgaris. Their findings suggest that ozenoxacin has a potent bactericidal activity against both levofloxacin-susceptible and -resistant P. acnes, and a long-lasting PAE against levofloxacin-susceptible P. acnes.
  • A study to determine the efficacy and safety of lactoferrin, combined with vitamin E and zinc, for mild to moderate acne vulgaris found that a twice daily regimen of lactoferrin with vitamin E and zinc significantly reduced acne lesions in people with mild to moderate acne vulgaris.
  • A new study shows evidence explaining the anti-inflammatory effect of Dermasence Refining Gel (DRG) in rosacea pathogenesis in vitro. The adjunctive use of DRG in mild to moderate rosacea as a topical cosmetic seems medically reasonable.
  • An uncontrolled, open-label clinical study in 40 cases of adult female acne (AFA) to investigate the effect of the facial mask on lesion count, sebum production (measured with the Sebutape® technique), and Global Acne Grading System (GAGS) scale found the ready-to-use peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved the cosmetic appearance of AFA by reducing cutaneous androgen content and promoting skin autophagy.

Clinical Reviews

  • In a new article, investigators review the evidence for the use of temporary, semi-permanent and permanent fillers for acne scars.
  • A meta-analysis that was performed to compare the clinical outcomes of fractional radiofrequency technique (fRF) with the fractional laser technique in Asians with atrophic acne scar found that fRF appears to be a superior alternative for the treatment of atrophic acne scar in Asians.
  • A study to compare the value of standardized skin surface biopsy (SSSB) and direct microscopic examination (DME) findings in reference to the clinical types (pityriasis folliculorum, rosacea type, acne type, and perioral type) and distribution patterns of demodicosis revealed that DME is a more sensitive method for detecting Demodex than SSSB, especially in patients with diffuse pattern and suspected rosacea type.
  • In the latest edition of the "Peer to Peer" audiocast series, Dr. Vincent DeLeo speaks with Dr. Cynthia L. Chen about the prescribing practices of US dermatologists regarding oral contraceptives (OCPs) for acne treatment.
  • Investigators in a new study surveyed 116 US dermatologists about their knowledge, comfort, and prescribing practices pertaining to the use of oral contraceptive pills (OCPs). The study indicated that many dermatologists believe the benefits of increased treatment efficacy may outweigh the risks.
  • A recent article discusses both clindamycin phosphate (CP) and tretinoin (Tret) as components of a topical aqueous-based combination gel that has been shown to be effective, safe, and well tolerated for treatment of facial AV. Clinically relevant considerations with use of this treatment are also discussed.
  • In a new article, investigators review the efficacy and side effect profiles of various lasers used to treat acne.
  • A recently published article focuses on the importance of raising awareness of autoinflammatory syndromes associated with hidradenitis suppurativa (HS) in order to optimize disease management and ultimately improve the quality of life of patients.
  • A meta-analysis, evidence-based examination of the relationship between isotretinoin and depression showed that isotretinoin treatment for acne does not appear to be associated with an increased risk for depression. Moreover, the treatment of acne appears to ameliorate depressive symptoms.
  • A study to determine standardized incidence estimates for hidradenitis suppurativa (HS) in the United States found that the average annual overall incidence over 10 years was 8.6 (95% CI, 8.6-8.7) per 100,000 population.
  • With new treatment options and enthusiasm for hidradenitis suppurativa (HS), further attention needs to be paid to the scoring systems or outcome measures that clinicians use to grade HS severity and disease. scoring systems for HS, particularly ones that accurately assess this impact of treatment, are essential.
  • A recent review demonstrates that there is insufficient evidence to either corroborate or refute delaying elective procedures in isotretinoin acne patients. Although the recent literature trends toward removing the procedural delay, the authors advocate for clinicians to consider the research presented in this review in the context of their own clinical experience and each individual patient's situation.

Patient Counseling / Communication

  • A study to measure the impact of wide local excision on quality of life in hidradenitis suppurativa (HS) Hurley grade III patients and to examine the rate of postoperative complications, disease recurrences, and satisfaction with the cosmetic results found that wide local excision significantly improves the quality of life of HS patients. Local recurrence rates are low, and satisfaction with the cosmetic results is high.
  • Investigators aimed to study the quality, popularity, readability, and timeliness of the most frequented websites on hidradenitis suppurativa (HS) found that, in addition to an increasing interest, there was a broad variation in the quality, readability, popularity, and timeliness of content on HS-related websites.
  • Three out of five teenagers surveyed by the British Skin Foundation said that the biggest impact acne has on their lives is a fall in self-confidence.
  • A recent review found the following indicators have been associated with acne in males: a higher body mass index (BMI) and waist-hip ratio (WHR) which correlate with greater body fat; higher levels of blood pressure, both systolic and diastolic; higher basal glucose concentrations; and higher insulin levels when challenged with an oral glucose tolerance test (OGTT).